Core PICU publications
Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial
Mailtand et al. BMC Medicine 2013, 11:68
Excess mortality from boluses occurred in all subgroups of children. Contrary to expectation, cardiovascular collapse rather than fluid overload appeared to contribute most to excess deaths with rapid fluid resuscitation. These results should prompt a re-evaluation of evidence on fluid resuscitation for shock and a re-appraisal of the rate, composition and volume of resuscitation fluids.